Publikationen der Arbeitsgruppe Biochemie sekundärer Pflanzenstoffe

Journale

• Chuang, L., Liu, S., Franke, J. (2023): Post-Cyclization Skeletal Rearrangements in Plant Triterpenoid Biosynthesis by a Pair of Branchpoint Isomerases,  Journal of the American Chemical Society 145:5083–5091
  DOI: https://doi.org/10.1021/jacs.2c10838
• Freke, R., Heinemann, B., Hakim, S.E., Witte, C.-P., Herde, M., Hildebrandt, T.M., Franke, J. (2023): Isotope-guided metabolomics reveals divergent incorporation of valine into different flavor precursor classes in chives,  ChemBioChem e202300056
  DOI: https://doi.org/10.1002/cbic.202300056
• Kwan, B.D., Seligmann, B., Nguyen, T.-D., Franke, J., Dang, T.-T.T. (2023): Leveraging synthetic biology and metabolic engineering to overcome obstacles in plant pathway elucidation,  Current Opinion in Plant Biology 71:102330.
  DOI: https://doi.org/10.1016/j.pbi.2022.102330
• Malhotra, K., Franke, J. (2023): Cytochrome P450 monooxygenase-mediated tailoring of triterpenoids and steroids in plants,  Beilstein Journal of Organic Chemistry 18:1289–1310
  DOI: https://doi.org/10.3762/bjoc.18.135
• Chuang, L., Enders, A., Offermann, S., Bahnemann, J., Franke, J. (2023): 3D-printed autoclavable plant holders to facilitate large-scale protein production in plants,  Engineering in Life Sciences 22:803–810
  DOI: https://doi.org/10.1002/elsc.202200001
• Chuang, L.; Liu, S.; Biedermann, D.; Franke, J. (2022): Identification of early quassinoid biosynthesis in the invasive tree of heaven (Ailanthus altissima) confirms evolutionary origin from protolimonoids.,  Frontiers in Plant Science 13:958138
  DOI: https://doi.org/10.3389/fpls.2022.958138
• Franke, J.; Zhang, Y.; Dang, T.-T. T. (2022): Editorial: Exploring and Engineering Plant Specialized Metabolism: Latest Advances and New Horizons.,  Frontiers in Plant Science, 12: 783465
  DOI: 10.3389/fpls.2021.783465
• Chuang, L.; Franke, J. (2022): Rapid Combinatorial Coexpression of Biosynthetic Genes by Transient Expression in the Plant Host Nicotiana Benthamiana.,  Engineering Natural Product Biosynthesis: Methods and Protocols; Skellam, E., Ed.; Methods in Molecular Biology; Springer US: New York, NY, 2022; pp. 395–420
  DOI: 10.1007/978-1-0716-2273-5_20
• Caputi, L.*; Franke, J.*; Bussey, K.; Farrow, S. C.; Vieira, I. J. C.; Stevenson, C. E. M.; Lawson, D. M.; O’Connor, S. E (2020): Structural basis of cycloaddition in biosynthesis of iboga and aspidosperma alkaloids,  Nat Chem Biol
  DOI: 10.1038/s41589-019-0460-x
• Trottmann, F.; Ishida, K.; Franke, J.; Stanišić, A.; Ishida‐Ito, M.; Kries, H.; Pohnert, G.; Hertweck, C. (2020): Sulfonium Acids Loaded onto an Unusual Thiotemplate Assembly Line Construct the Cyclopropanol Warhead of a Burkholderia Virulence Factor,  Angew Chem Int Ed
  DOI: 10.1002/anie.202003958
• Trottmann, F.; Franke, J.; Richter, I.; Ishida, K.; Cyrulies, M.; Dahse, H.-M.; Regestein, L.; Hertweck, C. (2019): Cyclopropanol Warhead in Malleicyprol Confers Virulence of Human‐ and Animal‐Pathogenic Burkholderia Species,  Angew. Chem. Int. Ed. 2019, 58, 14129–14133
  DOI: 10.1002/anie.201907324
• Franke, J.; Kim, J.; Hamilton, J. P.; Zhao, D.; Pham, G. M.; Wiegert-Rininger, K.; Crisovan, E.; Newton, L.; Vaillancourt, B.; Tatsis, E.; Buell, C. R., O’Connor, S. E. (2019): Gene discovery in Gelsemium highlights conserved gene clusters in monoterpene indole alkaloid biosynthesis,  ChemBioChem, 2019, 20, 83–87
  DOI: 10.1002/cbic.201800592
• Stein, A.; Compera, D.; Karge, B.; Brönstrup, M.; Franke, J. (2019): Isolation and characterisation of irinans, androstane-type withanolides from Physalis peruviana L.,  Beilstein J. Org. Chem. 2019, 15, 2003–2012
  DOI: 10.3762/bjoc.15.196
• Trottmann, F.;* Franke, J.;* Ishida, K.; García-Altares M.; Hertweck, C. (2019): A Pair of Bacterial Siderophores Releases and Traps an Intercellular Signal Molecule: An Unusual Case of Natural Nitrone Bioconjugation,  Angew. Chem. Int. Ed. 2019, 58, 200–204
  DOI: 10.1002/anie.201811131
• Caputi, L.; Franke, J.; Farrow, S.C.; Chung, K.; Payne, R.M.E.; Nguyen, T.-D.; Dang, T.-T.T.; Carqueijeiro, I.S.T.; Koudounas, K.; de Bernonville, T.D.; Ameyaw, B.; Jones, D.M.; Curcino Veira, I.J.; Courdavault, V.; O'Connor, S.E. (2018): Missing enzymes in the biosynthesis of the anticancer drug vinblastine in Madagascar periwinkle,  Science 2018, 360, 1235–1239.
  DOI: 10.1126/science.aat4100
• Dang, T.-T.T.*; Franke, J.*; Carqueijeiro, I.S.T.; Langley, C.; Courdavault, V.; O'Connor, S.E. (2018): Sarpagan bridge enzyme has substrate-controlled cyclization and aromatization modes,  Nat. Chem. Biol. 2018, 14, 760–763.
  DOI: 10.1038/s41589-018-0078-4
• Dang, T.T. , Franke, J., Tatsis, E., O’Connor, S.E. (2017): Dual Catalytic Activity of a Cytochrome P450 Controls Bifurcation at a Metabolic Branch Point of Alkaloid Biosynthesis in Rauwolfia serpentina,  Angew. Chem. Int. Ed. 2017, 56, 9440–9444.
  DOI: 10.1002/anie.201705010
• Tatsis, E.*, Carqueijeiro, I.*, Dugé de Bernonville, T., Franke, J., Dang, T.T., Oudin, A., Lanoue, A., Lafontaine, F., Stavrinides, A.K., Clastre, M., Courdavault, V., O’Connor, S.E. (2017): A three enzyme system to generate the Strychnos alkaloid scaffold from a central biosynthetic intermediate,  Nat. Commun. 2017, 8, 316.
  DOI: 10.1038/s41467-017-00154-x
• Franke, J.; Hertweck, C. (2016): Biomimetic Thioesters as Probes for Enzymatic Assembly Lines: Synthesis, Applications, and Challenges (Review),  Cell Chem. Biol. 2016, 23, 1179–1192­.
  DOI: 10.1016/j.chembiol.2016.08.014
• Baunach, M.; Franke, J.; Hertweck, C. (2015): Terpenoid Cyclizations Off the Beaten Track (Review),  Angew. Chem. Int. Ed. 2015, 54, 2604–2626.
  DOI: 10.1002/anie.201407883
• Ding, L.; Franke, J.; Hertweck, C. (2015): Divergolide congeners illuminate alternative reaction channels for ansamycin diversification,  Org. Biomol. Chem. 2015, 13, 1618–1623.
  DOI: 10.1039/c4ob02244k
• Franke, J.; Ishida, K.; Hertweck, C. (2015): Plasticity of the malleobactin pathway and its impact on siderophore action in human pathogenic bacteria,  Chem. Eur. J. 2015, 21, 8010–8014.
  DOI: 10.1002/chem.201500757
• Franke, J.*; Ishida, K.*; Hertweck, C. (2014): Evolution of Siderophore Pathways in Human Pathogenic Bacteria,  J. Am. Chem. Soc. 2014, 136, 5599–5602.
  DOI: 10.1021/ja501597w
• Xu, Z.; Baunach, M.; Ding, L.; Peng, H.; Franke, J.; Hertweck, C. (2014): Biosynthetic Code for Divergolide Assembly in a Bacterial Mangrove Endophyte,  ChemBioChem 2014, 15, 1274–1279.
  DOI: 10.1002/cbic.201402071
• Franke, J.*; Ishida, K.*; Ishida-Ito, M.; Hertweck, C. (2013): Nitro versus hydroxamate in siderophores of pathogenic bacteria: effect of missing hydroxylamine protection in malleobactin biosynthesis,  Angew. Chem. Int. Ed. 2013, 52, 8271–8275.
  DOI: 10.1002/anie.201303196
• Franke, J.*; Ishida, K.*; Hertweck, C. (2012): Genomics‐Driven Discovery of Burkholderic Acid, a Noncanonical, Cryptic Polyketide from Human Pathogenic Burkholderia Species,  Angew. Chem. Int. Ed. 2012, 51, 11611–11615
  DOI: 10.1002/anie.201205566